Severe liver injury due to Rupi Sanjie capsules (乳癖散结胶囊) and Xiangshao granules (香芍颗粒)
10.3760/cma.j.cn114015-20210223-00212
- VernacularTitle:联合应用乳癖散结胶囊和香芍颗粒致重度肝损伤
- Author:
Yanli MA
1
;
Yang ZHOU
;
Donglei ZHANG
;
Lijuan ZHANG
;
Meiying NING
;
Jing ZHAO
Author Information
1. 沧州市中心医院药学部，沧州 061001
- Publication Type:Journal Article
- Keywords:
Chemical and drug induced liver injury;
Rupi Sanjie capsules;
Xiangshao granules
- From:
Adverse Drug Reactions Journal
2022;24(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
A 25-year-old female patient took 4 Rupi Sanjie capsules orally (0.55 g/capsule) thrice daily and Xiangshao granules 1 bag (4 g/bag) orally thrice daily by herself for breast nodule. After 2 months, the patient developed yellow urine, skin itching, and yellowish skin and sclera. Laboratory tests showed alanine aminotransferase (ALT) 1 334 U/L, aspartate aminotransferase (AST) 717 U/L, alkaline phosphatase (ALP) 164 U/L, total bilirubin (TBil) 88 μmol/L, and γ-glutamyltransferase (γ-GT) 127 U/L. Liver injury caused by Rupi Sanjie capsules and Xiangshao granules were considered. The 2 drugs were stopped and the treatments of liver protection and cholagogic were given. Three weeks later, her symptoms above-mentioned disappeared and the laboratory tests showed ALT 106 U/L, AST 88 U/L, ALP 88 U/L, TBil 13 μmol/L, and γ-GT 32 U/L. At 1 month of follow-up, the patient′s liver function returned to normal. The patient′s liver injury might be related to the component of bupleurum in Rupi Sanjie capsules and Xiangshao granules and the component of prunella vulgaris in Rupi Sanjie capsules.
