Analysis of 281 cases of adverse reactions of drug-induced liver injury
10.3969/j.issn.1673-9701.2025.11.013
- VernacularTitle:281例药物性肝损伤不良反应分析
- Author:
Ling FAN
1
;
Qinhua GU
1
;
Yan WU
1
;
Xiaojing ZHU
1
Author Information
1. 苏州市中西医结合医院药剂科,江苏苏州 215101
- Publication Type:Journal Article
- Keywords:
Drug-induced liver damage;
Chinese medicine;
Anti-tumor drug;
Anti-tuberculosis drug
- From:
China Modern Doctor
2025;63(11):50-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore characteristics of patients with drug-induced liver injury(DILI),suspected drugs and outcomes,and to provide reference for clinical standard use of drugs and reduce adverse reactions of DILI.Methods Retrospective analysis of adverse drug reactions of 281 patients with DILI in Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from 2016 to 2023.Age,sex,severity,clinical manifestations,clinical classification,Roussel Uclaf causality assessment method(RUCAM)score,injury degree,combination,disease type,suspected drugs and outcomes of patiengs were statistically analyzed.Results Among 281 patients with DILI,there were 83 general ADRs cases and 198 serious ADRs cases.In terms of clinical manifestations,main manifestations were yellow skin sclera,poor appetite,fatigue and so on.In terms of injury degree,156 cases suffered mild liver injury,121 cases suffered moderate liver injury,and 4 cases suffered severe liver injury.There were 164 cases of combined drug use and 117 cases of single drug use.The top diseases of patients were tumor,respiratory disease,tuberculosis infection and so on.Among the suspected drugs,the top three drugs were Chinese medicine,anti-tumor drugs and anti-tuberculosis drugs in order,and there were significant differences between different types of suspected drugs and whether they were used in combination(P＜0.05).There were significant differences in clinical classification and effectiveness(P＜0.05).Conclusion Chinese medicine,anti-tumor drugs and anti-tuberculosis drugs are relatively easy to cause DILI.The type of liver cell damage,combination of drugs,types of diseases,and underlying diseases all affect the occurrence of DILI.
