Application of SAMP8 Mice in Anti-Aging Experiment
- VernacularTitle:SAMP8小鼠在抗衰老实验中的应用探析
- Author:
Guoqing WU
1
;
Zidong WANG
;
Zhibo JIAO
;
Jing JIANG
;
Junjian TIAN
;
Xiaoming GAO
;
Yinshan TANG
;
Zhongyi WANG
;
Zeyu MENG
;
Zhigang LI
Author Information
- Publication Type:Journal Article
- Keywords: The senescence accelerate mouse prone; Pathological changes; Animal experimental; Model application
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(12):3040-3052
- CountryChina
- Language:Chinese
- Abstract: The senescence accelerate mouse prone strain was identified by Professor T.Takeda's laboratory in Japan from the offspring produced by the brother-sister inbred line of AKR/J mice donated by Jackson Laboratory in the United States SAMP),and SAMP8 mice showed a variety of aging characteristics,such as:Pathological changes such as memory and learning disorders,behavioral abnormalities,skin roughness,aging,hair loss,eye lesions(visual impairment,cataract,periocular lesions),hearing impairment,weight loss,muscle strength loss,reproductive system aging,liver and fat metabolism disorders,etc.,are widely used in experimental studies of related diseases or pathology,and have made considerable contributions to the research of diseases.However,there are also many problems in its application,such as the selection of month age,the use of intervention methods,the suitability of pathological changes and research content,and the understanding of models under different theoretical backgrounds,which are of great research value.Therefore,this paper systematically analyzes the above problems based on existing literature,in order to provide relevant basis for the application of SAMP8 mice in different fields and different mechanisms.
