Correlation analysis between HPV infection,vaginal environment,and serum miRNA expression in patients with cervical cancer
10.12007/j.issn.0258-4646.2024.12.005
- VernacularTitle:宫颈癌患者HPV感染与阴道内环境和血清miRNA表达的相关性分析
- Author:
Haiying WANG
1
;
Yanmin ZHANG
1
;
Jia SU
1
;
Baoqin YANG
1
Author Information
1. 河南省中医院(河南中医药大学第二附属医院)检验中心,郑州 450053
- Publication Type:Journal Article
- Keywords:
human papilloma virus;
cervical cancer;
hydrogen peroxide;
sialidase;
miR-3607-3p;
miR-497-5p;
miR-501
- From:
Journal of China Medical University
2024;53(12):1088-1093
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between human papilloma virus (HPV) infection and the vaginal environment as well as serum microRNA (miRNA) expression in patients with cervical cancer. Methods A total of 100 patients with cervical cancer admitted to our hospital between October 2020 and June 2023 were enrolled and categorized into two groups:FIGO stage ⅠB (38 patients) and FIGO stage ⅡA (62 patients). Additionally,80 patients diagnosed with cervical intraepithelial neoplasia (CIN) during the same period were included as the precancerous lesion group. Positive rates of vaginal microenvironmental factors and serum miRNA expression levels were compared across the three groups,considering their different pathological characteristics. Results The high-risk HPV infec-tion rate was significantly higher in the FIGO stage ⅡA group compared to both the FIGO stage ⅠB and precancerous lesion groups (P<0.05). The proportion of patients with HPV viral load level 1 was significantly lower in the FIGO stage ⅡA group than in the FIGO stage ⅠB and precancerous lesion groups (P<0.05). The positivity rates of H2O2,SNA,pH,and LE in the FIGO stage ⅡA group were higher than those in the FIGO stage ⅠB and precancerous lesion groups (P<0.05). Serum miR-3607-3p and miR-497-5p levels in the FIGO ⅡA stage group were lower than those in the FIGO stage ⅠB and precancerous lesion groups,whereas serum miR-501 levels were higher compared with FIGO stage ⅠB and precancerous lesion groups (P<0.05). Significant differences in the expression levels of H2O2,SNA,pH,LE,serum miR-3607-3p,miR-497-5p,and miR-501 were observed across groups with varying pathological characteristics (P<0.05). Conclusion Tumor differentiation,HPV viral load,lymph node metastasis,FIGO stage,and levels of H2O2,SNA,pH,LE,serum miR-3607-3p,miR-497-5p,and miR-501 were closely correlated in patients with cervical cancer.
