Regulatory networks of skin wound healing:regeneration,fibrosis,and chronic wounds
10.12007/j.issn.0258-4646.2024.12.011
- VernacularTitle:皮肤创面愈合的调控网络:再生、纤维化和慢性创面
- Author:
Yimeng BI
1
;
Shanshan SONG
1
;
Yangzhi WEI
1
;
Zijian XU
1
;
Peng CHANG
1
Author Information
1. 中国医科大学附属盛京医院医疗整形美容科,沈阳 110004
- Publication Type:Journal Article
- Keywords:
wound healing;
regeneration;
fibrosis;
scar;
regulatory network
- From:
Journal of China Medical University
2024;53(12):1124-1128
- CountryChina
- Language:Chinese
-
Abstract:
Human skin self-repairs after trauma and surgery. During this process,the ability of the skin to achieve complete functional regeneration and avoid the formation of fibrosis (scarring) or chronic wounds is a key clinical concern. Studies on wound healing have suggested that several factors affect the process of wound healing,including race,age,wound site,and skin tension. However,the lack of systematic analysis of the complete definition and connotation of skin regeneration and fibrosis,as well as the key links in the regulatory network of wound healing,makes clinical application difficult. In this review,we discuss domestic and international literatures to formu-late the concept of skin regeneration and fibrosis,combine the latest research progress on the physiological and pathological processes of wound healing,and propose the key links of the regulatory network that can potentially affect the outcome of skin wound healing. There-fore,this review provides novel theoretical support for the study of wound healing and suggests innovative diagnostic and therapeutic strat-egies for clinical applications.
