Research progress on the mechanism and treatment of zinc finger protein A20 in psychiatric diseases
10.3969/j.issn.1002-0152.2024.12.010
- VernacularTitle:锌指蛋白A20在精神疾病中作用机制及治疗的研究进展
- Author:
Ying LI
1
;
Penghong LIU
;
Tao DONG
;
Zhifen LIU
Author Information
1. 山西医科大学医学科学院
- Publication Type:Journal Article
- Keywords:
Zinc finger protein A20;
Mental illness;
Depressive;
Bipolar disorder;
Schizophrenia;
Neuroinflam-mation;
Anti-inflammatory effect
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(12):760-764
- CountryChina
- Language:Chinese
-
Abstract:
The clinical efficacy of mental illness is not good.Therefore,it is particularly important to find new therapeutic targets and new drugs.At present,it has been found that neuroimmune response is closely related to psychiatric disorders.In addition a large number of studies have confirmed the mechanism of anti-inflammatory action of zinc finger protein A20(A20)in psychiatric disorders.A20 can inhibit the activation of a variety of inflammatory pathways,promote the transformation of microglia into an anti-inflammatory phenotype and exert its anti-inflammatory properties,alleviate neuroinflammation in the brain.Furthermore,A20 also prevent the activation of inflammatory cells in the central nervous system,reduce neuronal apoptosis,protect nerve cells from damage and alleviate psychiatric symptoms,thereby playing an important role in psychiatric diseases.Elucidating the above mechanisms of action could provide new insights into the pathogenesis of psychiatric disorders and provide possible targets for future therapeutic strategies.
