Relationship between platelet distribution width and coronary artery calcification in overweight and obese populations
10.13929/j.issn.1003-3289.2025.06.014
- VernacularTitle:超重及肥胖人群血小板分布宽度与冠状动脉钙化的相关性
- Author:
Chenyi WANG
1
;
Yongbing SUN
;
Zhi ZOU
;
Zhonglin LI
;
Xiaoling WU
;
Feifei SHANG
;
Min QU
;
Xiaolin ZHANG
;
Jiadong ZHU
;
Chunshi TONG
;
Yongli LI
Author Information
1. 河南省人民医院医学影像科,河南郑州 450003
- Publication Type:Journal Article
- Keywords:
obesity;
blood platelets;
coronary stenosis
- From:
Chinese Journal of Medical Imaging Technology
2025;41(6):914-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between platelet distribution width(PDW)and coronary artery calcification(CAC)in overweight and obese populations.Methods Clinical and chest CT data of 10 838 subjects with overweight or obesity(body mass index[BMI]≥24 kg/m2)were retrospectively analyzed.The subjects were divided into CAC group(n=4 237)and non-CAC group(n=6 601)based on CAC scores obtained from chest CT.The relationship between PDW and CAC in overweight and obese populations was analyzed after controlling confounding variables.A threshold effect analysis was conducted using a two-stage logistic model to find the non-linear inflection point.Subgroup analyses and interaction tests were conducted to validate the stability of the relationship between PDW and CAC.Results Non-linear relationship was observed between PDW and CAC risk in overweight and obese populations.The risk of CAC decreased with the increase of PDW which ≤17.80％(OR=0.82),but increased with the increase of PDW(OR=1.04)which＞17.80％.Subgroup analysis showed that the relationship between PDW and CAC remained stable in subgroups of different genders,BMI(＜28 kg/m2,≥28 kg/m2)and hypertension(all P＞0.05).Compared with aged＜40 years or ≥60 years subgroups,under the same PDW,aged≥40 and＜60 years subgroups had higher risk of CAC(interaction P=0.015).Conclusion Nonlinear relationship existed between PDW and CAC in overweight and obese populations.Both excessively high and low PDW were risk factors of CAC.
