Cefoperazone sodium sulbactam sodium-induced acute hemolysis in a child
10.3760/cma.j.issn.1008-5734.2020.02.008
- VernacularTitle:头孢哌酮钠舒巴坦钠致儿童急性溶血
- Author:
Shuang BAI
1
;
Mingyue LIU
1
;
Zhihui GENG
1
Author Information
1. 河北省保定市第一中心医院临床药学研究室 071000
- Publication Type:Journal Article
- Keywords:
Cefoperazone;
Sulbactam;
Hemolysis;
Child
- From:
Adverse Drug Reactions Journal
2020;22(2):103-104
- CountryChina
- Language:Chinese
-
Abstract:
A 4-year-old boy received an IV infusion of cefoperazone sodium sulbactam sodium 0.8 g once per 12 hours for severe pneumonia. On day 3 of the treatment, the child developed brown urine, abdominal pain, pale skin, and cold limbs at about 15 minutes of the infusion. Then the infusion was stopped immediately. Laboratory tests showed decreased red blood cell count 1.7×10 12/L(4.7×10 12 before treatment) and hemoglobin 67 g/L(121 g/L before treatment), reticulocyte 0.12, total bilirubin 54.7 μmol/L, indirect bilirubin 42.4 μmol/L, direct Coombs test positive, urine protein (++), urine occult blood (++), urobilinogen (+++), 87 urine red blood cells per high power field. The acute hemolysis caused by cefoperazone sodium sulbactam sodium was considered. The drug was discontinued immediately and IV infusion of methylprednisolone and other symptomatic treatments were given. Then the boy′s condition gradually improved. The anti infection treatment was replaced by azithromycin for injection. On day 9 of cefoperazone sodium sulbactam sodium withdrawal, the boy′s blood routine and urine routine returned to normal and the direct Coombs test was negative.
