Analysis of the Impact of Early Diabetic Kidney Disease on Brain Function and Cognitive Abilities via Resting-state Functional Magnetic Resonance Imaging
10.3969/j.issn.1005-5185.2025.02.005
- VernacularTitle:基于静息态功能磁共振成像探索早期糖尿病肾病对脑功能和认知能力的影响
- Author:
Miao HE
1
;
Bing JI
;
Liqing CHENG
;
Lan OU
;
Rui XIE
;
Jian WANG
Author Information
1. 陆军军医大学第一附属医院 7T磁共振转化医学研究中心/放射科,重庆 400038
- Publication Type:Journal Article
- Keywords:
Early diabetic kidney disease;
Resting state functional magnetic resonance imaging;
Amplitude of low-frequency fluctuations;
Functional connectivity;
Cognitive ability
- From:
Chinese Journal of Medical Imaging
2025;33(2):133-140
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze the impact of early renal complication on brain function in diabetes using the amplitude of low frequency fluctuations(ALFF)and functional connectivity(FC).Materials and Methods A total of 39 early diabetic kidney disease patients and 49 diabetic patients without kidney disease were included at the First Affiliated Hospital of Army Medical University from September 2023 to June 2024.Cognitive assessments were conducted using the Montreal cognitive assessment(MoCA)and mini-mental state examination(MMSE).All subjects underwent resting-state functional magnetic resonance imaging.Differences in brain function between the two groups were analyzed by ALFF and FC.In the early diabetic kidney disease group,the correlation and stepwise multiple linear regression analysis were performed between imaging difference indicators and clinical variables.Results In the early diabetic kidney disease patients,there was a decrease in ALFF values in the left calcarine(P<0.05,corrected for FWE),but an increase in FC with the left putamen(P<0.05,corrected for FWE).The ALFF values showed a negative correlation with urinary albumin-to-creatinine ratio and total cholesterol(r=-0.595,-0.351,both P<0.05)and a positive correlation with MoCA and MMSE scores(r=0.596,0.591,both P<0.001).The FC values were positively correlated with urinary albumin-to-creatinine ratio(r=0.552,P<0.001),while negatively correlated with MoCA and MMSE scores(r=-0.497,P=0.011;r=-0.529,P<0.001).Conclusion Early renal complications can affect changes in brain function and cognitive abilities in diabetic patients;alterations in the ALFF of the left calcarine and its FC with left putamen may serve as imaging biomarkers for monitoring cognitive impairment and brain injury in early diabetic kidney disease.
