Status epilepticus induced by carbamazepine poisoning
10.3760/cma.j.cn114015-20191125-00947
- VernacularTitle:卡马西平中毒致癫痫持续状态
- Author:
Xun LIU
1
;
Bo SUN
;
Huizhi ZHANG
;
Ying ZHANG
;
Baohong ZHAO
Author Information
1. 郑州市第二人民医院药务科，郑州 450006
- Publication Type:Journal Article
- Keywords:
Carbamazepine;
Poisoning;
Status epilepticus
- From:
Adverse Drug Reactions Journal
2020;22(10):583-584
- CountryChina
- Language:Chinese
-
Abstract:
A 24-year-old female patient took about 150 carbamazepine tablets (15 g). About 17 hours later, she was found unconscious and frequent convulsions by her family and was immediately sent to the hospital. Laboratory tests showed that the serum concentration of carbamazepine was 58.7 mg/L, creatine kinase was 411 U/L, C-reactive protein was 23.7 mg/L, and blood oxygen saturation was 0.78. Toxic encephalopathy and status epilepticus induced by carbamazepine were diagnosed. Oxygen inhalation, ECG monitoring, intravascular fluid supplement, diuresis, bedside blood filtration, and symptomatic and supportive treatments were given immediately. On the 2nd day, the number of epileptic seizures decreased and the serum concentration of carbamazepine decreased to 32.9 mg/L. On the 3rd day, the patient′s consciousness recovered and seizures occurred occasionally; on the 4th day, the serum concentration of carbamazepine decreased to 12.3 mg/L, and her convulsion disappeared. After 3 days of continued treatments, the patient recovered and discharged.
