Amylin regulates feeding through locus coeruleus
10.16303/j.cnki.1005-4545.2024.12.15
- VernacularTitle:Amylin通过蓝斑核(LC)调节采食
- Author:
Qi FAN
1
;
Haodong LIU
;
Penghui LI
;
Jiacheng LI
;
Xing WANG
;
Chenguang DU
Author Information
1. 内蒙古农业大学兽医学院,内蒙古呼和浩特 010018;内蒙古自治区基础兽医学重点实验室,内蒙古呼和浩特 010018
- Publication Type:Journal Article
- Keywords:
amylin;
locus coeruleus;
tyrosine hydroxylase;
thermogenesis;
mice
- From:
Chinese Journal of Veterinary Science
2024;44(12):2605-2611
- CountryChina
- Language:Chinese
-
Abstract:
Amylin exerts a satiety-limiting effect on food intake by influencing the regulation of en-ergy metabolism in the central nucleus.However,the binding sites of amylin are widely distributed throughout the central nervous system,and it remains unclear whether the locus coeruleus(LC)responds to amylin stimulation.Therefore,this experiment aims to confirm whether amylin exerts its inhibitory effect on food intake through the LC following localized damage to the LC nucleus.The results indicate that amylin,while suppressing appetite,activates c-Fos neurons and tyrosine hydroxylase(TH)within the LC,leading to increased heat production in the interscapular brown adipose tissue(IBAT)of mice.However,after LC damage,the central feeding inhibition mediated by amylin is alleviated,although it is weaker compared to the group with solely LC damage,and the thermogenic capacity of IBAT is reduced.Thus,the study demonstrates that the LC is also one of the sites of action for exogenous amylin and is crucial for maintaining amylin-induced thermo-genesis.These findings expand the understanding of amylin's central actions and ultimately provide potential targets for obesity treatment.
