Effect of multi-target high-frequency repetitive transcranial magnetic stimulation for freezing of gait in Parkinson's disease
- VernacularTitle:多靶点高频重复经颅磁刺激治疗帕金森病冻结步态的效果
- Author:
Zhen CHEN
1
;
Hui ZHANG
1
;
Zun-ke GONG
1
;
Hui ZHAO
1
;
Chen-xu LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Parkinson's disease; freezing of gait; repetitive transcranial magnetic stimulation; primary motor cortex; dorsolateral prefrontal cortex; motor symptoms
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(1):80-84
- CountryChina
- Language:Chinese
- Abstract: Objective To observe the clinical efficacy of multi-target repetitive transcranial magnetic stimulation on freezing of gait in Parkinson's disease. Methods A total of 45 Parkinson's disease patients with freezing of gait in our hospital from January 2023 to January 2024 were selected and randomly divided into primary motor cortex(M1) treatment group (M1 group),dorsolateral prefrontal cortex (DLPFC) group (D group),and M1+DLPFC group (MD group),with 15 cases in each group. The stimulation site of patients in M1 group was bilateral M1 region lower limb innervation region,the stimulation site of patients in D group was bilateral DLPFC,and the left M1 region and DLPFC region of patients in MD group were stimulated on alternate days. The efficacy of Parkinson's disease patients with freezing of gait and the changes of mood scores were compared among the groups. Results One patient in D group and one in MD group were lost to follow-up,and 43 patients were eventually included. The freezing of gait questionnaire (FOGQ) scores,timed up and go test (TUGT) total time,modified standing-start 180° turn test (SS-180) time,unified Parkinson's disease rating scale part Ⅲ(UPDRS Ⅲ) scores,Hamilton depression scale (HAMD) scores and Hamilton anxiety scale (HAMA) scores of patients after treatment were improved compared with those before treatment in all three groups (P<0.05),and the improvement effect of MD group was significantly better than those of M1 group and D group (P<0.05). Conclusion High-frequency repetitive transcranial magnetic stimulation targeting bilateral M1 region and DLPFC region can improve freezing of gait,walking ability,and motor function,and alleviate symptoms of depression and anxiety of Parkinson's disease patients.
