Research progress on TGF-β in peripheral nervous regeneration
- VernacularTitle:TGF-β在周围神经再生中的研究进展
- Author:
Li-qiang TANG
1
;
Yun QU
Author Information
- Publication Type:Journal Article
- Keywords: peripheral nerve regeneration; TGF-β signaling pathway; Schwann cells; Wallerian degeneration; macrophages
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(1):84-88
- CountryChina
- Language:Chinese
- Abstract: Peripheral nerve injury (PNI) is one of the most common issues among trauma patients.Treatment strategies for PNI typically involve surgical repair,rehabilitation therapy and medication management,but may still not achieve the expected therapeutic outcome. Following nerve injury,Schwann cells clear cellular debris,release growth-promoting factors and provide guidance support that promotes the regrowth of damaged nerve fibersand its reconnection to target tissues. The release of transforming growth factor beta (TGF-β) to the injury site after PNI can induce the transformation of astrocytes to an A2 phenotype,thereby upregulating the expression of neurotrophic factors. Meanwhile,TGF-β can initiate a series of phenotypic changes in Schwann cells,modulate immune cells,and activate the innate growth potential of neurons,thereby enhancing nerve regeneration potential. TGF-β can also promote angiogenesis,maintain the integrity of the blood-nerve barrier and enhance its permeability,thereby providing a beneficial microenvironment for nerve regeneration by inhibiting inflammation. This paper reviews the potential roles of TGF-β in peripheral nerve regeneration and investigates the underlying mechanisms,in order to provide new insights for better treatment of PNI.
