Diagnostic value of multi-slice computed tomography combined with serum interleukin-34 and monocyte chemoattractant protein-1 detection for active pulmonary tuberculosis
10.3760/cma.j.cn341190-20241009-01284
- VernacularTitle:MSCT联合血清IL-34、MCP-1检测对活动性肺结核的诊断价值研究
- Author:
Jiaoyang ZHANG
1
;
Jia GENG
;
Bin ZHANG
Author Information
1. 榆林市第三医院(榆林市传染病医院)影像科，榆林 718000
- Publication Type:Journal Article
- Keywords:
Tuberculosis,pulmonary;
Tomography,spiral computed;
Interleukins;
Monocyte chemoattractant proteins;
Diagnosis;
Sensitivity and specificity
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(9):1309-1314
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic value of multi-slice computed tomography (MSCT) combined with serum interleukin-34 (IL-34) and monocyte chemoattractant protein-1 (MCP-1) detection for active pulmonary tuberculosis.Methods:The clinical data of 80 patients with pulmonary tuberculosis admitted to Yulin Third Hospital from March 2021 to March 2024 who underwent MSCT examination and IL-34 and MCP-1 detection, were retrospectively analyzed. The patients were divided into an active pulmonary tuberculosis group ( n = 44) and an inactive pulmonary tuberculosis group ( n = 36) based on the results of the etiological examination. The differences in MSCT signs, IL-34 and MCP-1 levels were compared between the two groups. The accuracy, sensitivity, specificity, and consistency of MSCT combined with serum IL-34 and MCP-1 detection in the diagnosis of active pulmonary tuberculosis were evaluated taking the etiological examination as the gold standard. Receiver operating characteristic curves were used to analyze the diagnostic efficacy of MSCT combined with serum IL-34 and MCP-1 detection for active pulmonary tuberculosis. Results:In the active pulmonary tuberculosis group, the prevalences of the tree bud sign [63.16% (27/44)], ground-glass opacities [52.27% (23/44)], lung consolidation [45.45% (20/44)], and cavities [68.18% (30/44)] were significantly higher than those in the inactive pulmonary tuberculosis group [36.11% (13/36), 25.00% (9/36), 13.89% (5/36), 44.44% (16/36); χ2 = 5.05, 6.14, 9.18, 4.57, all P < 0.05]. The levels of IL-34 [(2 074.48 ± 338.81) ng/L] and MCP-1 [(315.89 ± 91.89) ng/L] in the active pulmonary tuberculosis group were significantly higher than those in the inactive pulmonary tuberculosis group [(1 655.56 ± 232.37) ng/L, (260.73 ± 123.73) ng/L, t = 6.54, 2.22, both P < 0.05]. Using the etiological results as the gold standard, the accuracy of MSCT in diagnosing active pulmonary tuberculosis was 87.50%, with a sensitivity of 86.36% and specificity of 88.89%. The Kappa value was 0.749, indicating good consistency. Receiver operating characteristic curve analysis showed that the area under the curve for MSCT, IL-34, and MCP-1, both alone and in combination, in diagnosing active pulmonary tuberculosis was 0.876, 0.835, 0.631, and 0.950, respectively. When using cutoff values, the sensitivity for MSCT, IL-34, and MCP-1, both alone and in combination, was 0.889, 0.750, 0.932, 0.609, and 0.944, respectively, while the specificity was 0.864, 0.861, 0.689, and 0.886, respectively. Conclusions:The results of MSCT are consistent with those of pathogen examination. MCP-1 has diagnostic value for active pulmonary tuberculosis. MSCT, IL-34, and the combination of MSCT, IL-34, and MCP-1 demonstrate a high diagnostic value for active pulmonary tuberculosis. The combination of MSCT, IL-34, and MCP-1 offers a new non-invasive diagnostic method for clinical practice, which holds great scientific importance and clinical application value.
