Regulatory effects and mechanisms of exosomes derived from stem cells and macrophages on colitis
10.3969/j.issn.1006-5725.2025.03.022
- VernacularTitle:干细胞和巨噬细胞来源的外泌体对结肠炎的调控作用及其机制
- Author:
Yijia LIU
1
;
Bin LIU
;
Kui HU
;
Yanfang CHEN
;
De CAI
Author Information
1. 广东医科大学附属医院药学部(广东 湛江 524001)
- Publication Type:Journal Article
- Keywords:
exosome;
colitis;
mesenchymal stem cell;
macrophage
- From:
The Journal of Practical Medicine
2025;41(3):447-453
- CountryChina
- Language:Chinese
-
Abstract:
Colitis is a common inflammatory bowel disease whose pathogenesis is related to immune regula-tion and intestinal microbial homeostasis.Exosomes are membrane vesicles secreted by cells that contain proteins,lipids,and other substances.Stem cells and macrophages can participate in the regulation of related diseases by secreting exosomes.It has been found that exosomes of stem cell and macrophage origin are closely involved in the regulation of colitis,and exosomes derived from stem cells,especially mesenchymal stem cells,play an important role in anti-colitis.This article reviews the role and possible mechanisms of mesenchymal stem cell-based and macrophage-derived exosomes in the regulation of colitis,aiming to provide ideas for in-depth study of colitis and new strategies for its treatment.
