Efficacy of alanyl glutamine combined with octreotide in the treatment of acute pancreatitis associated lung injury
10.3969/j.issn.1673-9701.2025.07.016
- VernacularTitle:丙氨酰谷氨酰胺联合奥曲肽治疗急性胰腺炎相关性肺损伤的疗效
- Author:
Honghua SHAO
1
;
Liang ZHU
;
Sha LI
;
Qiaoqiao CHEN
Author Information
1. 金华市中心医院药学部,浙江金华 321000
- Publication Type:Journal Article
- Keywords:
Alanyl glutamine;
Octreotide;
Acute pancreatitis;
Lung injury;
Toll-like receptor 4;
Matrix metalloproteinase-9
- From:
China Modern Doctor
2025;63(7):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of alanyl glutamine combined with octreotide in the treatment of acute pancreatitis(AP)associated lung injury.Methods A total of 94 patients with AP associated lung injury admitted to Jinhua Municipal Central Hospital from June 2022 to June 2024 were selected and divided into observation group and control group according to random number table method,with 47 patients in each group.Patients in control group were treated with octreotide,patients in observation group were treated with alanyl glutamine on the basis of control group.The efficacy,Balthazar CT grading,acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,Murray lung injury score(MLIS),Toll-like receptor 4(TLR4),matrix metalloproteinase-9(MMP-9)and blood gas indexes[arterial partial pressure of oxygen(PaO2),arterial oxygen saturation(SaO2)and oxygenation index]were compared between two groups.Results The curative effect of observation group was significantly better than that of control group(x2=5.817,P=0.016).After treatment,the Balthazar CT grading,APACHE Ⅱ score,MLIS score,TLR4 and MMP-9 of patients in two groups were significantly lower than before treatment,while PaO2,SaO2 and oxygenation index were significantly higher than before treatment(P＜0.05).Balthazar CT grading,APACHE Ⅱ score,MLIS score,TLR4 and MMP-9 in observation group were significantly lower than those in control group,while PaO2,SaO2 and oxygenation index were significantly higher than those in control group(P＜0.05).Conclusion Alanyl glutamine combined with octreotide has a significant effect in the treatment of patients with AP associated lung injury,which can improve the clinical symptoms of patients,reduce lung injury and inflammation.
