Screening and analysis of cancer-related differences of LncRNAs in patients with oral lichen planus based on high throughput sequencing technology
10.3969/j.issn.1001-3733.2025.01.013
- VernacularTitle:基于高通量测序技术对口腔扁平苔藓患者相关癌变差异LncRNAs的筛选与分析
- Author:
Wenliang DONG
1
;
Yidan HUANG
;
Wenzhuo GUO
;
Huixia YANG
;
Jing ZHANG
Author Information
1. 750004 银川,宁夏医科大学总医院口腔医院牙体牙髓病科
- Publication Type:Journal Article
- Keywords:
LncRNAs;
Oral lichen planus;
High-throughput sequencing;
Bioinformatics analysis;
Canceration
- From:
Journal of Practical Stomatology
2025;41(1):80-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To screen and analyze the carcinogenesis-related differential expression profile of long non-coding RNAs(LncRNAs)in oral lichen planus(OLP)mucosa tissue,and preliminarily analyze their functions,to explore their possible role in the development of OLP.Methods:High-throughput sequencing technology was used to construct differential expression profile from 5 cases of erosive OLP lesions and 5 of normal oral mucosa.LncRNAs that are closely related to the carcinogenesis of OLP were ob-tained by bioinformatics analysis.Results:400 LncRNAs associated with OLP were screened,of which 250 were up-regulated and 150 were down-regulated,and 5 LncRNAs were obtained with differential expression associated with OLP carcinogenesis:LncRNA 54055,100128560,399717,378825 and 100130231.Conclusion:400 LncRNAs are differentially expressed in the mucosa of erosive OLP lesions,and 5 of them are related to the incidence and carcinogenesis tendency of OLP.
