Pathogen distribution and antibiotic resistance analysis of 69 cases of necrotizing fasciitis
10.3969/j.issn.1673-9701.2025.06.012
- VernacularTitle:69例坏死性筋膜炎患者的病原菌分布与细菌耐药性分析
- Author:
Yingbin CHEN
1
;
Yintao HUANG
;
Jiabao SHOU
;
Rui SONG
Author Information
1. 柳州市工人医院创伤修复烧伤整形外科,广西柳州 545005
- Publication Type:Journal Article
- Keywords:
Necrotizing fasciitis;
Pathogen distribution;
Antibiotic resistance;
Pathogen detection;
Antibiotics
- From:
China Modern Doctor
2025;63(6):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the pathogen distribution and antibiotic resistance characteristics of 69 cases of necrotizing fasciitis(NF),providing evidence to support early clinical antimicrobial therapy.Methods A retrospective analysis was conducted on microbial culture and antibiotic susceptibility test results from 69 NF cases treated in the Department of Trauma Repair and Burn Plastic Surgery,Liuzhou Workers'Hospital from January 2017 to December 2023.Results A total of 77 bacterial strains were cultured,including 24 Gram-positive bacteria,48 Gram-negative bacteria,and 5 fungi.Monomicrobial infection was predominant,accounting for 66.07％of the cases.Among the Gram-positive bacteria,Staphylococcus aureus was the most common,separated out 10 strains(12.99％),followed by Streptococcus pyogenes in 5 strains(6.49％).Among the Gram-negative bacteria,Klebsiella pneumoniae(13 strains,16.88％)and Escherichia coli(10 strains,12.99％)were most frequently identified.A total of 18 multidrug-resistant strains were found,representing 23.38％of all isolates.Gram-positive bacteria were most sensitive to vancomycin,linezolid,and tigecycline,while Gram-negative bacteria showed the greatest sensitivity to meropenem,cefoperazone,and ertapenem.Conclusion In the study area,Klebsiella pneumoniae is the most common pathogen causing NF.The initial antimicrobial regimen should include vancomycin combined with meropenem,which may significantly enhance the effectiveness of infection control.
