Changes of lipid peroxidation and antioxidant capacity in patients with hypercholesterolemia
10.3969/j.issn.1673-9701.2025.07.003
- VernacularTitle:高胆固醇血症患者脂质过氧化及抗氧化能力的变化
- Author:
Chunxin NA
1
;
Qiong LIU
;
Zhuoke YU
;
Mengqi JI
;
Yueqiao YAN
;
Ying ZHAO
;
Fengyan JIANG
;
Zhongyan YANG
Author Information
1. 七台河市人民医院检验科,黑龙江七台河 154600
- Publication Type:Journal Article
- Keywords:
Hypercholesterolemia;
Lipid peroxidation;
Antioxidant
- From:
China Modern Doctor
2025;63(7):11-13,31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of lipid peroxidation and antioxidant capacity in patients with hypercholesterolemia.Methods A total of 100 patients with elevated cholesterol treated in the People's Hospital of Qitaihe from January to May 2024 were included in hypercholesterolemia group,and another 80 people with normal blood lipid in the hospital during the same period were included in control group.Malondialdehyde(MDA),glutathione(GSH),glutathione reductase(GR)and total antioxidant capacity(TAC)were determined in all subjects.Results The levels of total cholesterol,low density lipoprotein-cholesterol and MDA in hypercholesterolemia group were significantly higher than those in control group,while the levels of GSH,GR and TAC were significantly lower than those in control group(P＜0.05).Conclusion Patients with hypercholesterolemia have severe lipid peroxidation,which may cause vascular endothelial cell damage.
