Causal associations between micronutrients concentrations and the risk of immune-mediated inflammatory skin diseases by using Mendelian randomization study
10.3969/j.issn.1673-9701.2025.06.005
- VernacularTitle:应用孟德尔随机化研究微量营养素与免疫介导的炎症性皮肤病风险之间的因果关系
- Author:
Susu JIN
1
;
Liru SONG
1
;
Xiujing LIU
1
;
Yingying WANG
1
;
Jiao SHAO
1
Author Information
1. 温州医科大学附属第二医院临床检验中心,浙江温州 325000
- Publication Type:Journal Article
- Keywords:
Micronutrients;
Mendelian randomization study;
Atopic dermatitis;
Psoriasis;
Urticaria
- From:
China Modern Doctor
2025;63(6):24-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential causal links between micronutrient levels and the risk of immune-mediated inflammatory skin disease(IMID).Methods Leveraging publicly accessible genome-wide association study(GWAS)datasets,fifteen specific micronutrients were identified as exposure variables,while four prevalent IMID:Psoriasis,atopic dermatitis,urticaria,and alopecia areata were designated as study outcomes.Robust instrumental variables were meticulously selected to facilitate the Mendelian randomization analysis.The main assessment used the inverse-variance weighting(IVW)method,complemented by an assortment of Mendelian randomization methodologies,inclusive of MR-Egger,weighted median estimate(WME)and weighted mode(WM).Rigorous sensitivity analyses were conducted to bolster the robustness of the findings.Results Vitamin D exhibited a significant inverse association with the risk of psoriasis(OR=0.996,P=0.001,95％CI:0.994-0.998),corroborated by consistent trends across WME,MR-Egger,and WM methods.Phosphorus demonstrated a positive correlation with urticaria risk(OR=5.634,95％CI:1.792-17.711,P=0.003),with findings in alignment with WME and WM methods.Copper was found to be positively associated with atopic dermatitis risk(ORIVW=1.234,P=0.0007,95％CI:1.092-1.394),and vitamin E levels were significantly related to the risk of urticaria(OR=26.643,P=0.013,95％CI:1.981-358.333).Sensitivity analysis did not show heterogeneity and pleiotropy(P＞0.05).Conclusion The study establishes a causal relationship between vitamin D levels and the risk of psoriasis,suggesting that augmenting vitamin D intake could be a viable dietary intervention for psoriasis prevention.These findings offer novel insights into the preventative and therapeutic strategies for IMID.
