Study on the effectiveness of modified cardiac rehabilitation and Xuefu Zhuyu decoction in treating Qi deficiency and blood stasis type heart failure based on Gal-3 and sST2 levels
10.3969/j.issn.1673-9701.2025.06.004
- VernacularTitle:基于Gal-3和sST2水平的气虚血瘀型心力衰竭患者改良心脏康复与血府逐瘀汤治疗效果研究
- Author:
Feikai WU
1
;
Meixia XIAO
;
Shengming SHI
;
Haibing LIU
;
Shasha ZHANG
Author Information
1. 湖州市第一人民医院全科医学科,浙江湖州 313000
- Publication Type:Journal Article
- Keywords:
Heart failure;
Qi deficiency and blood stasis type;
Galectin-3;
Soluble suppression of tumorigenicity 2;
Left ventricular ejection fraction;
6-minute walk test
- From:
China Modern Doctor
2025;63(6):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of modified cardiac rehabilitation combined with Xuefu Zhuyu decoction on patients with heart failure of Qi deficiency and blood stasis type,with a focus on analyzing the improvement of galectin-3(Gal-3),soluble suppression of tumorigenicity 2(sST2)levels,cardiac function,traditional Chinese medicine syndromes,and exercise tolerance.Methods 180 patients with heart failure of Qi deficiency and blood stasis type who attended the Department of Rehabilitation Medicine,Huzhou First People's Hospital from October 2021 to March 2023 were selected and randomly divided into treatment group(modified cardiac rehabilitation+Xuefu Zhuyu decoction)and control group(conventional treatment),with a treatment course of 12 weeks.The changes of Gal-3,sST2,left ventricular ejection fraction(LVEF),New York heart association functional classification(NYHA),N-terminal B-type natriuretic peptide(NT-proBNP),traditional Chinese medicine syndrome score and 6-minute walk test(6MWT)were compared between two groups before and after 12 weeks of treatment,and the safety was evaluated.Results After 12 weeks of treatment,Gal-3 and sST2 levels of patients in treatment group were significantly lower than those in control group;LVEF levels of patients in treatment group were significantly higher than those in control group,and the degree of improvement of cardiac function grading in treatment group was significantly better than that in control group;NT-proBNP in treatment group was significantly lower than that in control group;The 6MWT in treatment group was significantly higher than that in control group;The score of traditional Chinese medicine syndrome in treatment group was lower than that in control group;The difference is statistically significant(P＜0.05).After 12 weeks of treatment,the effective rate of treatment group was significantly higher than that of control group(P＜0.05);There was no statistically significant difference in adverse reactions and serious adverse events between two groups of patients(P＞0.05).Conclusion Modified cardiac rehabilitation combined with Xuefu Zhuyu decoction can significantly improve cardiac function,traditional Chinese symptoms,and exercise tolerance in patients with heart failure of Qi deficiency and blood stasis type,reduce Gal-3 and sST2 levels,and has high clinical application value.
