Research on modulation of fear memory at different time windows by ketamine
10.3969/j.issn.1000-4718.2025.01.021
- VernacularTitle:氯胺酮调节不同时间窗口恐惧记忆的研究进展
- Author:
Yufan FANG
1
;
Hongji WANG
;
Yuxuan HE
;
Han WANG
;
Lin SUN
Author Information
1. 山东第二医科大学临床医学系,山东 潍坊 261053
- Publication Type:Journal Article
- Keywords:
post-traumatic stress disorder;
ketamine;
conditioned fear memory;
consolidation;
reconsolida-tion;
extinction
- From:
Chinese Journal of Pathophysiology
2025;41(1):181-187
- CountryChina
- Language:Chinese
-
Abstract:
Post-traumatic stress disorder(PTSD)is a severe mental disorder that significantly impacts an indi-vidual's health,with its primary symptom being fear-based memories.In the pathological state of PTSD,fear-based memo-ries are prolonged and intensified by certain physiological mechanisms.Therefore,expediting the extinction of fear-based memories and preventing their excessive consolidation are crucial for successful treatment.Recently,researchers have dis-covered that ketamine,beyond its role as an anesthetic,also plays a substantial part in regulating fear-based memories.This paper aims to elucidate the role of ketamine in modulating conditioned fear-based memories across various time frames and brain regions,as well as the associated molecular mechanisms.Furthermore,it seeks to clarify the specificity of dif-ferent molecular mechanisms in distinct time frames of fear-based memories and assess whether ketamine could be a prima-ry medication for treating PTSD.
