Traditional Chinese medicine compound in treating idiopathic membranous nephropathy network Meta-analysis
10.3969/j.issn.1673-9701.2025.05.017
- VernacularTitle:中药复方治疗特发性膜性肾病的网状Meta分析
- Author:
Jingxue BAI
1
;
Genping LEI
;
Ting WANG
;
Sheng DONG
;
Jiongdong XIE
;
Xian LU
;
Dong YANG
Author Information
1. 陕西中医药大学第一临床医学院中医系,陕西咸阳 712046
- Publication Type:Journal Article
- Keywords:
Compound Chinese medicine;
Idiopathic membranous nephropathy;
Net work Meta-analysis
- From:
China Modern Doctor
2025;63(5):62-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effectiveness and safety of different traditional Chinese medicine(TCM)prescriptions combined with conventional western drugs to improve idiopathic membranous nephropathy(IMN)based on the Chinese medicine evidence system.Methods A computerized search of databases was conducted to collect randomized controlled trials(RCTs)of TCM compound formulas combined with conventional western medicines for the treatment of IMN,with a search timeframe from the establishment of the database to October 2023.Thirty-five RCTs involving six interventions and containing 2518 IMN patients were finally included.The quality of the included literature was evaluated.Reticulated Meta-analysis was performed,and surface under the cumulative ranking(SUCRA)curve was used to rank the clinical efficacy and safety of the six interventions,aiming to provide an evidence-based basis for the rational clinical selection of prescriptions for treating patients with IMN.Results The formula of tonifying deficiency and eliminating stasis combined with conventional western medicine showed significant effects in lowering 24-hour urine protein quantification(SUCRA=95.3％)and total cholesterol level(SUCRA=98.2％).The formula of tonifying deficiency,eliminating stasis,purging heat,and dispelling dampness combined with conventional western medicine was effective in lowering blood creatinine(SUCRA=80.4％)and increasing serum albumin level(SUCRA=72.9％).The formula of tonifying deficiency and clearing heat and dampness combined with conventional western medicine was more effective in lowering M-type phospholipase A2 receptor antibody titer(SUCRA=86.0％).Conclusion In terms of safety,the adverse effects of the TCM compound formula combined with conventional western drugs were overall less than those of conventional western drugs alone.
