Mitophagy in cardiovascular diseases
10.3969/j.issn.1000-4718.2025.00.001
- VernacularTitle:线粒体自噬在心血管疾病中的作用
- Author:
Shaohua LU
1
;
Haixia ZHUANG
;
Chen ZHU
;
Du FENG
Author Information
1. 广州医科大学基础医学院,广州市呼吸疾病全国重点实验室,广东省蛋白质修饰与降解重点实验室,广东 广州 511436;广州医科大学附属第四医院,广东 广州 510250
- Publication Type:Journal Article
- Keywords:
cardiovascular diseases;
mitochondria;
mitophagy
- From:
Chinese Journal of Pathophysiology
2025;41(1):142-156
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases(CVD)remain a leading cause of mortality worldwide,with complex pathogenic mechanisms.Mitochondrial dysfunction,a key hallmark in CVD pathology,disrupts cellular homeostasis through oxidative stress,calcium imbalance,and reduced ATP production,ultimately damaging cardiomyocytes.Mitopha-gy,a selective autophagy process,plays a crucial protective role by degrading dysfunctional mitochondria,thus maintain-ing mitochondrial quality and quantity balance in cells.Recent studies have highlighted the significant regulatory role of mitophagy in various CVD pathological processes,including heart failure,myocardial infarction,ischemia/reperfusion in-jury,hypertension,and atherosclerosis.Notably,a variety of drugs have been shown good potential in the targeted regula-tion of mitophagy activity,which provides a new idea for the treatment of CVD.This review systematically elucidates the latest advances in understanding the molecular mechanisms,pathophysiological functions,and potential therapeutic appli-cations of mitophagy in CVD.It provides a theoretical foundation for deepening our comprehension of CVD pathogenesis and developing innovative treatment strategies,offering new insights into cardiovascular disease management.
