Progress in Basic Research on Antihypertensive Effects of Medicinal and Edible Homologous Traditional Chinese Medicine
- VernacularTitle:药食同源类中药抗高血压基础研究进展
- Author:
Quan ZHOU
1
;
Gaochuan ZHANG
1
;
Jiamin ZHANG
1
;
Yi ZHAO
1
;
Hongning LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: Medicine and food are homologous; Hypertension; Traditional Chinese medicine; Active ingredients; Mechanism
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(1):132-142
- CountryChina
- Language:Chinese
- Abstract: Hypertension is one of the important causes of premature death worldwide,and the prevention and treatment of hypertension is of great significance in reducing the incidence and mortality rate of cardiovascular disease.Antihypertensive drugs and food homologous traditional Chinese medicine have the advantages of easy access,high safety,and minimal side effects.Based on the list of 101 traditional Chinese medicinal materials that are both medicinal and food substances released by the National Health Commission,a search was conducted on 101 Chinese medicinal materials related to hypertension using the China National Knowledge Infrastructure(CNKI).The screening criteria are single drug,extract,or monomer therapy for hypertension,and the number of literature is≥2,resulting in 14 medicinal and food homologous traditional Chinese medicines with antihypertensive effects.Search for 14 Chinese medicine names and hypertension keywords on PubMed,Web of Science,and Google Scholar to collect reports on the treatment of hypertension with medicinal and food homologous traditional Chinese medicine.Based on the search results of China National Knowledge Infrastructure,summarize their classification,drug properties,efficacy,antihypertensive effects,and mechanism of action,in order to provide inspiration for new prescriptions,drug development,and functional foods for treating hypertension.Most of the antihypertensive traditional Chinese medicines with the same origin as medicine and food belong to the categories of clearing heat and tonifying deficiency;Most drugs have a sweet and spicy taste,which belongs to the liver,spleen,and kidney meridians.The efficacy is mostly to clear the liver and brighten the eyes,tonify the liver and kidneys,promote qi circulation,dispel blood stasis,and disperse nodules.It mainly inhibits ACE activity;Reduce REN and AngⅡ levels;Upregulate SOD levels and reduce MDA expression;Improve the expression level of NO/NOS;Enhance antioxidant effects;Improve endothelial function;Relieve inflammatory reactions;Various methods such as reducing target organ damage can play a role in treating hypertension.
