Study on self-injurious and suicidal behavior,non-enzymatic antioxidants and thyroid hormones in adolescents with depressive disorder
10.3969/j.issn.1673-9701.2025.05.005
- VernacularTitle:青少年抑郁症自伤自杀行为与非酶类抗氧化物及甲状腺激素水平分析
- Author:
Xuefei WANG
1
;
Manman CHEN
;
Yuxin TENG
;
Botao ZENG
Author Information
1. 济宁医学院精神卫生学院,山东济宁 272067
- Publication Type:Journal Article
- Keywords:
Suicidal behavior;
Self-injurious behavior;
Non-enzymatic antioxidants;
Thyroid hormones
- From:
China Modern Doctor
2025;63(5):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between self-injurious and suicidal behavior in adolescents with depressive disorder and their non-enzymatic antioxidants and thyroid hormones.Methods A total of 93 adolescent patients with depressive disorder who were hospitalized at the Qingdao Mental Health Center from August 2023 to May 2024 were selected as the research subjects.The patients were divided into three groups:depression group(n=33),self-injurious behavior group(n=30)and a suicidal behavior.Plasma levels of non-enzymatic antioxidants and thyroid hormones were measured at admission and after 8 weeks of treatment,and their clinical symptoms were assessed by the Hamilton depression scale(HAMD)and the Hamilton anxiety scale(HAMA).Differences in plasma non-enzymatic antioxidants and thyroid function levels and scale scores were compared among three groups.Results Compared with depression group,baseline UA levels were lower in self-injurious and suicidal behavior groups.After 8 weeks of treatment,FT3 levels were higher in self-injurious group than in the suicidal behavior group,and both HAMD and HAMA scores decreased in all patients.After correction,HAMA scores were higher in suicidal behavior group than in depression group(P=0.047).Compared to baseline levels,TSH levels increased,and HAMD and HAMA scores decreased in all groups after treatment(P＜0.001).In suicidal behavior group,TBIL and FT3 levels decreased,and UA levels increased after treatment,while in depression group,FT4 levels decreased after treatment.Conclusion Non-enzymatic antioxidants may serve as potential biological markers for adolescents with depressive disorder who exhibit self-injurious and suicidal behavior.
