Clinicopathologic characteristics and prognostic analysis of follicular thyroid carci-nomas
10.13315/j.cnki.cjcep.2025.01.009
- VernacularTitle:甲状腺滤泡癌的临床病理特征和预后分析
- Author:
Hongqun WANG
1
;
Xin SONG
;
Peng LIU
;
Youjie GONG
;
Ying LI
;
Huaiyin SHI
Author Information
1. 解放军总医院第一医学中心病理科,北京 100853;蚌埠市第三人民医院病理科,蚌埠 233099
- Publication Type:Journal Article
- Keywords:
thyroid neoplasm;
follicular thyroid carcinoma;
FTC with undifferentiated cancer;
distant metastasis;
number of cancer foci;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(1):51-59
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathologic characteristics and prognostic factors of follicular thyroid carcinomas(FTC).Methods The clinical and pathological data of 205 FTC patients were collected,and the clinico-pathologic characteristics of FTC and its impact on prognosis were analyzed.Results The most common site of metas-tasis of FTC was bone(25.4％),which were mainly vertebrae and pelvis,followed by lung(15.6％).The factors that affecting distant metastasis(DM)were as follows:≥2 tumor foci,stage(Ⅲ-Ⅳ),patients'age(≥55 years,ex-tensive invasive type,recurrent FTC,postoperative/post-treatment recurrence and metastasis,and patients with com-plete tumor resection had less DM(P＜0.05,respectively).The factors that affecting the number of tumor foci includ-ed age,stage(Ⅲ-Ⅳ),extensive invasive type,recurrent FTC,distant metastasis and history of hypertension,more recurrence and metastasis after surgery/treatment(P＜0.05,respectively).Univariate survival analysis showed that factors affecting the overall survival(OS)and cancer-specific survival(CSS)of FTC were as follows:the number of tumor foci,stage,patients'age,surgical mode,extensive invasive type,DM,smoking,and postoperative/post-treat-ment recurrence.Cox multivariate regression analysis showed that stage,smoking and distant metastasis affected OS and/or CSS,and stage,extensive invasive type and recurrent FTC affected relapse-free survival(RFS).Compared with the group of FTC without undifferentiated carcinoma(UTC),the group of FTC with UTC had later stage(Ⅲ-Ⅳ,100.0％vs 32.0％),older age(≥ 60 years old,87.5％vs 37.6％),bigger size(＞4 cm,100.0％vs 44.2％),higher proportion of extensive infiltration type(100.0％vs 33.3％),shorter survival time[CSS(4.429±1.152)months vs(120.415±5.765)months,P＜0.001].Conclusion The most common site of distant metastasis of FTC is bone.Older patients,extensively invasive type and recurrent cancer are prone to multifocal and distant me-tastases.There were many prognostic factors affecting of FTC.The group of FTC with UTC has worse prognosis.
