Prognostic value of neutrophil-to-lymphocyte ratio and glycemic variability in patients with sepsis
10.3969/j.issn.1673-9701.2025.05.015
- VernacularTitle:中性粒细胞/淋巴细胞比值、血糖变异度对脓毒症患者预后的预测价值
- Author:
Danyu LI
1
;
Jiali YAO
1
;
Hongjie TONG
1
;
Kun CHEN
1
Author Information
1. 金华市中心医院重症医学科,浙江金华 321000
- Publication Type:Journal Article
- Keywords:
Glycemic variability;
Neutrophil-to-lymphocyte ratio;
Sepsis
- From:
China Modern Doctor
2025;63(5):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of neutrophil-to-lymphocyte ratio(NLR)and glycemic variability(GV)in patients with sepsis.Methods A total of 121 sepsis patients hospitalized in Jinhua Central Hospital from January 2023 to January 2024 were selected and divided into survival group(n=68)and death group(n=53)according to whether they died within 28d of confirmed sepsis.Blood glucose levels on the first 1-3 days after the diagnosis of sepsis were collected,and GV was calculated.The risk factors impacting the prognosis of patients with sepsis were analyzed through binary Logistic regression.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of relevant indicators.Results Compared with survival group,the levels of neutrophil count,acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ),procalcitonin,NLR and GV levels in death group were significantly increased(P＜0.05),while lymphocyte was decreased(P＜0.05).Logistic regression analysis indicated that NLR and GV might be independent risk factors affecting the prognosis of sepsis patients(P＜0.05).ROC curve showed area under the curve(AUC)of NLR was 0.814 and GV AUC was 0.805.Conclusion NLR and GV could potentially be independent risk factors affecting the prognosis of sepsis patients,and they hold a certain degree of predictive worth for the prognosis of sepsis patients.
