PANoptosis:analyzing new dimension of cell death and its research progress in related diseases
10.12360/CPB202403062
- VernacularTitle:PANoptosis:解析细胞死亡的新维度在相关疾病中的研究进展
- Author:
Jun SHAO
1
;
Na-qi LIAN
;
Yu LI
;
Mian-li BIAN
Author Information
1. 南京中医药大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
PANoptosis;
mechanisms;
immunity;
inflamma-tion;
tumor;
clinical application
- From:
Chinese Pharmacological Bulletin
2025;41(2):214-218
- CountryChina
- Language:Chinese
-
Abstract:
Programmed cell death is known to play a crucial role in host defense,with various cell death pathways having u-nique regulatory mechanisms.In recent years,further research into cell death pathways has revealed crosstalk and coordination among them,leading to the proposition of a new cell death path-way:PANoptosis.PANoptosis is believed to be an inflammatory form of programmed cell death regulated by the PANoptosome complex,possessing key features of pyroptosis,apoptosis,and ne-croptosis,and it cannot be solely characterized by any single mode of cell death.PANoptosis is involved in various diseases,such as infectious diseases and tumor-related conditions,where specific triggers can induce host cell death via the PANoptosis pathway.In-depth investigation of PANoptosis promises a better understanding of the complex regulatory network of cell death and may offer new therapeutic targets for diseases.This review provides an overview of the specific mechanisms underlying PANoptosis and its potential roles in various diseases such as cancer,infectious diseases,and cardiovascular disorders.
