Research on traditional Chinese medicine improving neurodegenerative diseases based on mitochondrial dynamics
10.12360/CPB202403021
- VernacularTitle:基于线粒体动力学的中药改善神经退行性疾病研究
- Author:
Zi-yang ZHAO
1
;
Hao-nan SHI
;
Yang GENG
;
Lei ZHANG
;
Qian-qian FENG
;
Yan-yan JIANG
;
Shi-fen DONG
Author Information
1. 北京中医药大学中药学院
- Publication Type:Journal Article
- Keywords:
mitochondrial dynamics;
mitochondrial transport;
mitochondrial autophagy;
mitochondrial fission-fusion;
neurode-generative diseases;
Chinese materia medica;
natural products
- From:
Chinese Pharmacological Bulletin
2025;41(2):201-207
- CountryChina
- Language:Chinese
-
Abstract:
Disorders of mitochondrial dynamics are closely re-lated to the development of neurodegenerative diseases(NDDs),which are characterized by the loss of neurons in brain and spinal cord cells.Diseases such as Alzheimer's disease,Parkinson's disease,Huntington's disease,and so on are in-volved in NDDs,which are often accompanied by disorders of mi-tochondrial dynamics during the development of these diseases.Recently,the researches on mitochondrial dynamics to study the pathogenesis of neurodegenerative diseases and related medica-tion innovation have garnered significant attention.This review focuses on the fundamental molecular processes of mitochondrial dynamics,such as mitochondrial transport,mitochondrial autoph-agy,and mitochondrial fission-fusion,and their molecular mecha-nisms in the pathogenesis of NDDs.It also outlines the recent research progress on Chinese materia medica and natural prod-ucts in ameliorating NDDs by modulating mitochondrial dynam-ics.The aim is to establish a foundation for researching innova-tive traditional Chinese medicine for NDDs-related diseases by focusing on mitochondrial dynamics.
