Retrospective study on prognostic risk following radical cystectomy combined with Mainz Pouch Ⅱ reservoir for bladder cancer
10.12354/j.issn.1000-8179.2025.20241390
- VernacularTitle:膀胱癌根治性膀胱切除术联合Mainz Pouch Ⅱ代膀胱术后的预后风险回顾性观察研究
- Author:
Mo CHUNHAO
1
;
Chen CHUANJIAN
1
;
Zhang SHAOLONG
1
;
Dong ZHICHUN
1
;
Pei ZHUOXI
1
;
Wang ZHIPING
1
;
Hou ZIZHEN
1
;
Ding HUI
1
Author Information
1. 兰州大学第二医院泌尿外科(兰州市 730030)
- Publication Type:Journal Article
- Keywords:
Mainz Pouch II;
radical cystectomy;
bladder cancer
- From:
Chinese Journal of Clinical Oncology
2025;52(2):75-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to evaluate the prognostic factors of clinical and histopathological parameters,including age,gender,tumor stage,tumor grade,tumor differentiation,lymph node metastasis(LNM),tumor frequency,and tumor count,in patients undergoing radical cystectomy(RC)combined with Mainz Pouch Ⅱ bladder reconstruction.Methods:A total of 237 bladder cancer patients(198 male and 39 female)who underwent RC combined with Mainz Pouch Ⅱ bladder reconstruction without chemotherapy or radiotherapy,from January 2004 to January 2023,were included in this study.Kaplan-Meier and Cox regression analyses were performed to assess the impact of age,tumor grade,tumor stage,tumor differentiation,LNM,tumor frequency,and tumor count on 5-year overall survival(OS)and 5-year cancer-specific survival(CSS).Results:The mean age at diagnosis was 59.8 years,with 198 male and 39 female patients.The mean follow-up duration was 47.8 months.In univariate analysis,patients younger than 65 years had significantly higher 5-year OS and 5-year CSS compared to those aged≥65 years.Patients with urothelial carcinoma showed better 5-year OS than those with non-urothelial carcinoma.Additionally,tumor stage,tumor grade,and LNM were negatively associated with 5-year OS and 5-year CSS.On multivariate analysis,only tumor grade and LNM remained statistically significant(P<0.05).Conclusions:Tumor grade and LNM were identified as independent prognostic risk factors for 5-year OS and 5-year CSS following RC combined with Mainz PouchⅡ bladder reconstruction.Moreover,the application of RC combined with Mainz Pouch Ⅱ bladder reconstruction should consider the patient's preferences and physical condition.
