Progress of Research on Role of Interleukin-13 in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2024.06.010
- VernacularTitle:白细胞介素-13在炎症性肠病中作用的研究进展
- Author:
Wenyang BAO
1
;
Ke CHEN
;
Menglei FAN
;
Xiaohui HUANG
;
Ruyi WANG
;
Qianqian SHI
;
Xiaoyun WANG
Author Information
1. 江南大学附属中心医院(无锡市第二人民医院)消化内科(214002);南通大学无锡临床学院
- Publication Type:Journal Article
- Keywords:
Interleukin-13;
Inflammatory Bowel Disease;
Intestinal Fibrosis
- From:
Chinese Journal of Gastroenterology
2024;29(6):376-381
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a chronic non-specific gastrointestinal disorder of unknown etiology and its global incidence is increasing.The traditional view holds that interleukin-13(IL-13)only plays an anti-inflammatory role,but recent studies have demonstrated that IL-13 also plays a pro-inflammatory role by disrupting the intestinal epithelial barrier and forming intestinal fibrosis and intestinal fistula through the IL-13 receptor alpha 2(IL-13Rα2)-mediated pathway.This article reviewed the progress of research on the role of IL-13 in IBD,aiming to provide a reference for optimizing the treatment of IBD.
