The clinicopathological characteristics of prostate cancer patients with low level PSA
10.12354/j.issn.1000-8179.2025.20250180
- VernacularTitle:低血清前列腺特异性抗原前列腺癌的临床病理特征
- Author:
Liu SIRU
1
;
He HUIYING
Author Information
1. 北京大学医学部临床医学系(北京市 100191)
- Publication Type:Journal Article
- Keywords:
low PSA;
prostate cancer(PCa);
neuroendocrine prostate cancer(NEPC);
clinicopathological characteristics
- From:
Chinese Journal of Clinical Oncology
2025;52(10):527-532
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer(PCa)is one of the common malignant tumors of the genitourinary system in men.It is generally believed that the serum prostate-specific antigen(PSA)level exceeding 4.0 ng/mL has potential diagnostic value for PCa.However,there are many cases of PCa with low PSA levels in clinical practice,specifically between 0-4.0 ng/mL.These cases may be missed or even misdiagnosed due to low PSA levels,leading to delays in treatment and missing the optimal clinical window for diagnosis and treatment.This review provides a com-prehensive summary of the clinicopathological characteristics of PCa patients with PSA levels below 4.0 ng/mL,including their baseline and clinical features,histological characteristics,imaging features,neuroendocrine prostate cancer(NEPC)and prognostic factors,aiming to en-hance the understanding of this type of PCa.
