Research progress on molecular mechanisms of breast cancer lung metastasis from a multi-omics perspective
10.12354/j.issn.1000-8179.2025.20250296
- VernacularTitle:多组学视角下乳腺癌肺转移的分子机制研究进展
- Author:
Yu LANYA
1
;
He ZHE
;
Wu JUNHAN
;
Qiao GUIBIN
Author Information
1. 中国人民解放军南部战区总医院普通外科(广州市 510000)
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
neoplasm metastasis;
lung neoplasm;
multi-omics
- From:
Chinese Journal of Clinical Oncology
2025;52(9):474-479
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer remains one of the most prevalent malignancies among women worldwide,with distant organ metastasis being the leading cause of mortality.The lungs are a common site of metastasis in breast cancer and are associated with significantly poor prognosis.Although notable progress has been made in therapeutic strategies,efficacy remains markedly limited once pulmonary metastasis develops.Therefore,elucidating the molecular mechanisms that drive pulmonary metastasis,characterizing the immune microenvironment,and as-sessing therapeutic responsiveness are critical.Recent advances in multi-omics approaches-including genomics,transcriptomics,proteomics,metabolomics,and epigenetics-have been widely applied to investigate breast cancer metastasis,offering new insights into the complex mo-lecular networks underlying pulmonary dissemination.This review synthesizes current findings on key genes,proteins,metabolites,and epi-genetic regulatory mechanisms involved in the metastatic cascade from a multi-omics perspective.
