Potential Role of Cuproptosis in Spinal Cord Injury
10.13865/j.cnki.cjbmb.2024.08.1222
- VernacularTitle:铜死亡在脊髓损伤中的潜在作用
- Author:
Hong-Xia CHENG
1
;
Fen-Fen MA
1
;
Ya-Hui CHEN
1
Author Information
1. 延安大学医学院生理教研室,陕西 延安716000
- Publication Type:Journal Article
- Keywords:
spinal cord injury (SCI);
cuproptosis;
mitochondria (Mc);
copper ions (Cu);
cuproptosis-related genes (CRGs)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(12):1666-1672
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a serious disease of the central nervous system,and its complex patho-genesis has always been the focus of research.Secondary injury is the main cause of neurological dysfunc-tion after spinal cord injury,in which mitochondrial dysfunction,inflammatory response,and ionic im-balance are important pathological processes in the secondary injury stage.Cuproptosis is a new mode of cell death that occurs by direct binding of copper to the thiooctylated component of the tricarboxylic acid cycle,leading to aggregation of thiooctylated proteins and the loss of iron-sulphur cluster proteins ulti-mately leading to cell death.The occurrence of cuproptosis involves two important factors,mitochondria and copper ions,and cuproptosis-related genes that regulate its occurrence have also been proposed.Cu-proptosis is thought to be relevant to the pathogenesis of spinal cord injury because of the impaired mito-chondrial function and abnormal serum copper levels that occur after spinal cord injury.In this paper,we discuss the link between cuproptosis and spinal cord injury by taking cuproptosis regulating mitochondrial function,affecting copper ion metabolism,and some cuproptosis-related genes (FDX1,LIAS,DLD,PDHA1,and PDHB) as an entry point,to provide theoretical basis and support for the clinic of spinal cord injury.
