Research progress on the effects of lactic acid on tumor immune microenvironment and immunotherapy
10.12354/j.issn.1000-8179.2025.20250102
- VernacularTitle:乳酸对肿瘤免疫微环境及免疫治疗影响的研究进展
- Author:
Chen YAN
1
;
Hu ZENAN
;
Jiang LEI
Author Information
1. 兰州大学第一临床医学院(兰州市 730000)
- Publication Type:Journal Article
- Keywords:
lactic acid;
tumor immune microenvironment(TIME);
immunotherapy;
drug resistance
- From:
Chinese Journal of Clinical Oncology
2025;52(8):407-412
- CountryChina
- Language:Chinese
-
Abstract:
An increasing number of studies have demonstrated that lactic acid,a key signaling molecule,plays a critical role in tumorigenes-is,immunotherapy response,and cellular metabolism regulation.Immunotherapy has become a mainstay of cancer treatment;however,most patients fail to respond,which may stem from the tumor immune microenvironment(TIME).Lactic acid,a central metabolic modulat-or of the tumor immune response,accumulates in the TIME and suppresses immune cell activity,thereby promoting tumor growth and im-mune escape.Targeting lactate metabolism and its associated pathways presents a novel strategy to overcome immunotherapy resistance.This article reviews current research on the regulatory mechanism of lactic acid in the TIME and immunotherapy,providing new ideas for combating tumor immunotherapy resistance.
