Effect of low-molecular-weight heparin anticoagulant drugs in the treatment of venous thrombosis caused by viral pneumonia
10.3969/j.issn.1673-9701.2025.18.014
- VernacularTitle:低分子肝素类抗凝药物治疗病毒性肺炎所致静脉血栓的疗效比较
- Author:
Yu LIU
1
;
Ye LI
;
Pengcheng DUAN
;
Yinmei LI
;
Mengyi QIAO
Author Information
1. 云南省第一人民医院 昆明理工大学附属医院药学部,云南 昆明 650032
- Publication Type:Journal Article
- Keywords:
Low-molecular-weight heparin;
Anticoagulant drugs;
Viral pneumonia;
Venous thromboembolism
- From:
China Modern Doctor
2025;63(18):64-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of low-molecular-weight heparin anticoagulant drugs in the treatment of venous thrombosis caused by viral pneumonia.Methods The clinical data of 355 patients diagnosed with viral pneumonia patients in the First People's Hospital of Yunnan Province from December 2022 to February 2023 were collected by retrospective analysis.The patients were classified into moderate group(n=1 14),severe group(n=116),and critical group(n=125)based on the severity of viral pneumonia.The changes in coagulation indicators of the patients after treatment with low molecular weight heparin sodium injection,low molecular weight heparin calcium injection,and enoxaparin sodium injection were compared among three groups.Results Compared with before treatment,there was no statistically significant difference in white blood cells count among three groups of patients after treatment(P＞0.05);The hypersensitive C-reactive protein levels of patients in moderate group and critical group decreased(P＜0.05);The levels of D-dimer decreased in severe group and critical group of patients(P＜0.05).After treatment with low-molecular-weight heparin calcium injection,the activated partial thromboplastin and prothrombin time of patients in severe group were shortened compared to before treatment,and the D-dimer levels of patients in severe group and critical group were reduced compared to before treatment,with statistical significance(P＜0.05);After treatment with low-molecular-weight heparin sodium and enoxaparin,only critical group showed a significant decrease in D-dimer levels(P＜0.05).Conclusion Low-molecular-weight heparin calcium injection has a stronger alleviating effect on blood hypercoagulability caused by elevated D-dimer levels than low-molecular-weight heparin sodium and enoxaparin,which is beneficial for relieving patients' hypercoagulability.
