Survival analysis of newly diagnosed non-transplant multiple myeloma patients
10.3760/cma.j.cn341190-20240912-01172
- VernacularTitle:初诊非移植多发性骨髓瘤患者生存分析
- Author:
Jianxia HUANG
1
;
Jushan ZHANG
;
Ning WANG
;
Guoliang ZHANG
;
Yuxia WANG
;
Yan WANG
;
Qing WU
Author Information
1. 武威市人民医院血液内科，武威 733000
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Root cause analysis;
Prognosis;
Cause of death;
Renal insufficiency;
Kidney failure, chronic
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(4):523-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze overall survival (OS), influential factors, and causes of death in patients with newly diagnosed non-transplant multiple myeloma (NDMM) at grassroots hospitals.Methods:The clinical data of 56 patients with NDMM admitted to the Department of Hematology, Wuwei People's Hospital from January 2018 to October 2022 were retrospectively analyzed. Using the Kaplan-Meier and Cox regression survival analysis models, univariate and multivariate analyses were performed to evaluate the factors affecting the OS of patients with NDMM.Results:The median OS of patients with NDMM was 27 months. Univariate analysis indicated that whether or not to receive chemotherapy was a risk factor affecting OS. Multivariate analysis revealed that age ( HR: 2.215, 95% CI 1.056-4.648, P < 0.05), renal dysfunction ( HR: 3.482, 95% CI 1.359-8.923, P < 0.05), and whether or not to receive chemotherapy ( HR: 0.83, 95% CI 0.021-0.331, P < 0.001) were all significant risk factors affecting OS (all P < 0.05). Conclusions:The median survival time of patients with NDMM is short. Age, renal dysfunction, and not receiving chemotherapy are unfavorable factors affecting OS. Pulmonary infection, renal failure, and disease progression are the main causes of death in patients with NDMM.
