Analysis of influencing factors and TCM syndrome classification of skin pruritus in patients with maintenance hemodialysis
10.3969/j.issn.1673-9701.2025.17.006
- VernacularTitle:维持性血液透析患者皮肤瘙痒的影响因素分析及中医证候分型研究
- Author:
Yuanying XIA
1
;
Xiaoping FAN
1
;
Xiaojuan FANG
1
;
Liyan ZHANG
1
;
Yi ZHANG
1
Author Information
1. 浙江中医药大学附属嘉兴中医医院血液净化中心,浙江嘉兴 314000
- Publication Type:Journal Article
- Keywords:
Maintenance hemodialysis;
Skin pruritus;
Influencing factors;
Traditional Chinese medicine syndrome classification
- From:
China Modern Doctor
2025;63(17):20-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors and Traditional Chinese Medical(TCM)syndrome classification of skin pruritus in patients with maintenance hemodialysis(MHD).Methods A total of 174 hemodialysis patients who underwent regular dialysis in Zhejiang Chinese Medical University Affiliated Jiaxing TCM Hospital from July to September 2024 were selected as study subjects.According to the presence or absence of uremic pruritus(UP),they were divided into pruritus group(n=66)and non-pruritus group(n=108).Both groups of patients were classified into TCM syndromes,and the factors affecting skin pruritus in MHD patients were analyzed by Logistic regression analysis and an evaluation model was established.The evaluation efficiency of the model was evaluated by receiver operating characteristic curve.The relationship between TCM syndromes and pruritus degree was analyzed.Results Both groups of patients were mainly characterized by spleen and kidney Qi deficiency,and the difference was statistically significant(P＜0.05).Logistic regression analysis showed that β2 microglobulin(β2-MG),blood phosphorus,hyper-sensitive C-reactive protein and parathyroid hormone(PTH)were all risk factors for skin pruritus in MHD patients.The area under the curve of skin pruritus in MHD patients was 0.962(95％CI:0.930-0.995).The underlying syndrome of UP patients was mainly spleen and kidney Qi deficiency,and marked syndrome was mainly blood deficiency and wind-dryness.Conclusion β2-MG,blood phosphorus,hyper-sensitive C-reactive protein and PTH are closely related to the occurrence of skin pruritus in MHD patients.The TCM syndrome of UP patients is mainly characterized by spleen and kidney Qi deficiency,and syndrome of blood deficiency and wind-dryness is mainly characterized by UP patients,and there is a certain correlation between TCM syndrome classification and the degree of skin pruritus.
