Severe liver injury caused by Sanqi Shangyao tablets(三七伤药片)
10.3760/cma.j.cn114015-20230920-00688
- VernacularTitle:三七伤药片致重度肝损伤
- Author:
Lizhen CHEN
1
;
Xiufen CHEN
1
;
Xuemei YANG
1
Author Information
1. 第九〇九医院/厦门大学附属东南医院药剂科，漳州 363000
- Publication Type:Journal Article
- Keywords:
Phytotherapy;
Drug-induced liver injury;
Aconitine;
Sanqi Shangyao tablets;
Chinese patent drugs
- From:
Adverse Drug Reactions Journal
2024;26(7):440-441
- CountryChina
- Language:Chinese
-
Abstract:
A 60-year-old male patient with lumbar disc herniation and sciatica received Sanqi Shangyao 3 tablets thrice daily orally by himself. After 6 days of administration, the patient developed upper abdominal stuffy pain, nausea, vomiting, and yellowish skin. Laboratory tests showed total bilirubin (TBil) 155.2 μmol/L, direct bilirubin (DBil) 87.1 μmol/L, alanine aminotransferase (ALT) 817 U/L, aspartate aminotransferase (AST) 367 U/L, and alkaline phosphatase (ALP) 136 U/L. The concentration of γ-glutamyltransferase (GGT) was 455 U/L. The drug was stopped, liver protective treatments were given for 8 days, and the above symptoms in the patient were improved; after 38 days of treatments, laboratory tests showed TBil 27.3 μmol/L, DBil 9.3 μmol/L, ALT 46 U/L, AST 28 U/L, ALP 83 U/L, and GGT 55 U/L. The patient′s liver injury was possibly related to the aconitine contained in the Radix Aconiti Kusnezoffii and Aconitum racemulosum Franch of Sanqi Shangyao tablets.
