Acute renal failure caused by afatinib
10.3760/cma.j.cn114015-20220929-00884
- VernacularTitle:阿法替尼致急性肾衰竭
- Author:
Dongqin WU
1
;
Zhihong QIN
;
Zhixiang YANG
;
Huabo WEI
Author Information
1. 重庆市丰都县人民医院药学部，重庆 408200
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Acute kidney injury;
Kidney failure;
Afatinib;
Adverse drug reaction
- From:
Adverse Drug Reactions Journal
2023;25(12):755-756
- CountryChina
- Language:Chinese
-
Abstract:
A 73-year-old male patient with right lung squamous cell carcinoma developed edema of bilateral lower limbs, poor appetite, and oliguria after targeted treatment with afatinib 30 mg once daily orally for 80 days. The laboratory tests showed serum creatinine 658 mmol/L, blood urea 26.8 mmol/L, urine protein (++++), and urine occult blood (+++). Renal biopsy showed renal tubular injury, some cells appearing as crescents, and mild IgA deposition. Acute kidney failure was diagnosed, which was considered to be caused by afatinib. Afatinib was stopped and symptomatic treatments including hemodialysis, glucocorticoids, anticoagulants, diuretics, etc. were given. Twelve days later, the edema in both lower limbs was alleviated;19 days later, his daily urine volume was approximately 800 ml; 99 days later, his renal function indicators tended to be normal. The patient did not receive targeted treatment again.
