Adaptive evolution of drug resistance and virulence of Klebsiella pneumoniae in hosts during treatment period
10.11816/cn.ni.2025-240907
- VernacularTitle:肺炎克雷伯菌在宿主治疗期间耐药性和毒力的适应性进化
- Author:
Yongjin HU
1
;
Zengpeijie DAN
1
;
Jian LU
1
Author Information
1. 上海交通大学医学院附属第一人民医院急诊危重病科,上海,200080
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
In vivo;
Adaptive evolution;
Resistance;
Virulence
- From:
Chinese Journal of Nosocomiology
2025;35(5):788-794
- CountryChina
- Language:Chinese
-
Abstract:
To adapt to the immune environment and the stress of antimicrobial exposure,Klebsiella pneumoniae can evolve into resistance to multiple antimicrobial agents in the hosts.However,less attention has been paid to the genetic evolution in vivo from antimicrobial susceptibility to resistance.This paper reviews the adaptive evolu-tion of drug resistance and virulence of K.pneumoniae in patients in current clinical practice.The potential mecha-nisms of the evolution of resistance to carbapenems,ceftazidime-avibactam,tigecycline and colistin in human hosts were mainly summarized.
