Research progress on ferritinophagy in cancer intervention

VernacularTitle:铁蛋白自噬在肿瘤干预中的研究进展
Author: Weihua ZHENG ¹ ; Zihang WANG ; Long XUA ; Caiyan AN ; Yali YAN ; Yu ZHANG ; Hongquan WANG ; Junjing ZHANG
Author Information

1. 呼和浩特市第一医院基础与转化医学研究中心，呼和浩特　010030
Publication Type:Journal Article
Keywords: Ferritins; Autophagy; Ferroptosis; Neoplasm; Intervention
From: Chinese Journal of Hepatobiliary Surgery 2025;31(7):549-552
CountryChina
Language:Chinese
Abstract: Ferroptosis is an iron-dependent cell death modality triggered by the accumulation of lipid peroxides and is closely linked to tumor pathogenesis. Ferritinophagy refers to the selective autophagic degradation of ferritin, releasing intracellular stored iron to maintain iron metabolic homeostasis. This process is also significantly associated with tumor-targeted interventions. This review systematically elucidates the mechanisms of ferroptosis and ferritinophagy, their roles in tumor progression, and the therapeutic potential of pharmacologically induced ferritinophagy in anticancer strategies.