Research progress on immune pathogenesis of vitiligo
10.3969/j.issn.1000-484X.2025.02.042
- VernacularTitle:白癜风免疫发病机制的研究进展
- Author:
Kaixiao LI
1
;
Wen HU
1
;
Xiaojing KANG
1
Author Information
1. 新疆维吾尔自治区人民医院皮肤性病科,新疆皮肤病临床医学研究中心,新疆皮肤病研究重点实验室,乌鲁木齐 830001
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Pathogenesis;
Cellular immunity;
Humoral immunity
- From:
Chinese Journal of Immunology
2025;41(2):503-509
- CountryChina
- Language:Chinese
-
Abstract:
Vitiligo is a depigmentation skin disease caused by the progressive destruction of autologous epidermal melano-cytes.However,the mechanism of melanocyte dysfunction and death is unclear.It is worth noting that most melanocyte deaths in patients with vitiligo are directly caused by autoimmune response.There are many immune related cell molecules in the body,such as CD8+T cells,IFN-γ and inflammatory cytokines all play a role in the pathogenesis of vitiligo.To clarify the effects of body immunity,cytokines and autoantibodies on the normal function of melanocyte and their role in the condition of vitiligo can provide a basis for finding the treatment of vitiligo.
