Application of multimodal imaging technology in the staging of cervical cancer and evaluation of pathological differentiation
10.3760/cma.j.cn341190-20240415-00410
- VernacularTitle:多模态影像学技术在宫颈癌分期及病理分化程度评估中的应用
- Author:
Zhenhua JIAO
1
;
Chenchen QIN
1
Author Information
1. 咸阳市中心医院影像中心，咸阳 712000
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Magnetic resonance imaging;
Diffusion magnetic resonance imaging;
Neoplasm staging;
Neoplasm grading
- From:
Chinese Journal of Primary Medicine and Pharmacy
2024;31(12):1784-1788
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the application value of multimodal imaging technology in the staging of cervical cancer and evaluation of pathological differentiation.Methods:A cross-sectional study was conducted to retrospectively analyze the clinical data of 83 patients with cervical cancer who received treatment at Xian Yang Central Hospital from February 2022 to September 2023. All patients underwent pelvic magnetic resonance imaging (MRI), including diffusion-weighted imaging (MRI-DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A double-blind method was used to compare the DWI parameters [apparent diffusion coefficient (ADC), slow diffusion coefficient (D), and fast diffusion coefficient (D*)] and DCE parameters [volume transfer constant (K trans), rate constant (K ep), and extracellular volume fraction (V e)] among patients with different clinical stages and histological grades. The application value of multimodal MRI in the staging of cervical cancer and evaluation of pathological differentiation was analyzed. Results:The ADC values in patients with cervical cancer at stage Ⅰb and below were significantly higher than those in patients with cervical cancer at stages Ⅱa, Ⅱb, and Ⅲ and above ( F = 7.90, P < 0.01). Conversely, the K trans, K ep, and V e values were all lower in patients with cervical cancer at stage Ⅰb and below than those in patients with cervical cancer at stages Ⅱa, Ⅱb, and Ⅲ and above ( F = 8.12, 7.64, 3.13, all P < 0.01). For patients with cervical cancer at stage Ⅱa, the ADC value was (0.84 ± 0.15), which was higher than that of patients with cervical cancer at stage Ⅲ and above (0.76 ± 0.07) ( t = 1.88, P = 0.035). The K trans, K ep, and D* values were (0.29 ± 0.09), (0.53 ± 0.13), and (39.08 ± 7.30), respectively, all of which were lower than those in patients with cervical cancer at stage III and above [(0.39 ± 0.12), (0.69 ± 0.18), (49.04 ± 6.72), t = -2.64, -2.85, -3.94, all P < 0.01]. The ADC values in G1 grade patients were higher than those in G2 and G3 grade patients ( F = 4.26, P < 0.05), while the K trans, K ep, and D* values were all lower than those in G2 and G3 grade patients ( F = 8.14, 6.83, 6.81, all P < 0.05). Pearson correlation analysis showed that the histological grade of patients with cervical cancer was negatively correlated with the ADC value ( r = -0.32, P = 0.003) and positively correlated with the K trans, K ep, and D* values ( r = 0.43, 0.35, 0.28, all P < 0.05). Conclusion:Multimodal imaging technology has good application value in evaluating the clinical staging and pathological differentiation of cervical cancer, making them worthy of clinical reference and application.
