Research progress of exosomes in allergen immunotherapy
10.3969/j.issn.1000-484X.2025.02.040
- VernacularTitle:外泌体在过敏原免疫治疗中的研究进展
- Author:
Jianjian DENG
1
;
Yi QIU
1
;
Chunping YANG
1
Author Information
1. 南昌大学第二附属医院,南昌 330006
- Publication Type:Journal Article
- Keywords:
Exosomes;
Allergy;
Allergic diseases;
Allergen immunotherapy
- From:
Chinese Journal of Immunology
2025;41(2):490-494
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are extracellular vesicles secreted by cells with lipid bilayer structure.As an important carrier of intercel-lular communication,exosomes are involved in regulating various pathological and physiological processes of the body.Exosomes can be used by immune cells to enhance or suppress immune response,and exosomes play an important role in allergic sensitization and in-flammation,in which mast cell-derived exosomes can absorb IgE and down-regulate IgE levels in the whole body.Tolerogenic exo-somes can inhibit allergic immune response by inducing regulatory T cells.Exosomes promote Th1 response to allergens;exosomes can also regulate IgE to promote antigen presentation,so exosomes are one of the development directions of immunotherapy.This article reviews the relationship between exosomes and allergic diseases and the progress in allergen specific immunotherapy.
