Sepsis-associated delirium and disorder of neuroendocrine immune regulation
10.3969/j.issn.1000-484X.2025.02.036
- VernacularTitle:脓毒症相关性谵妄与神经内分泌免疫调控紊乱
- Author:
Aixin LIU
1
;
Congli SUN
;
Xiaomin KANG
;
Lijie LIU
Author Information
1. 东南大学医学院,南京 210009
- Publication Type:Journal Article
- Keywords:
Sepsis-associated delirium;
Neuroendocrine immune network;
Neuroinflammation;
Inflammatory factor
- From:
Chinese Journal of Immunology
2025;41(2):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-associated delirium(SAD)is a common and severe central nervous system(CNS)complication in patients with sepsis,whose occurrence mechanism is unclear and there is no effective treatment at present.Neuroendocrine immune regulation disorder is closely related to occurrence and development of SAD.Immune mediators can deliver peripheral immune information to CNS by humoral transport or through afferent nerves.Immune mediators invading center can not only directly damage neurons,but also activate innate immune cells of brain,further aggravate neuroinflammation,and cause neurotransmitter imbalance,neurotoxic effects,resulting in neuronal dysfunction,even apoptosis and subsequent behavioral and cognitive symptoms.This paper aims to review mechanisms of neuro-endocrine-immune regulation in occurrence and development of SAD,and to find effective targets for prevention and treatment of sepsis and SAD.
