Analysis of curative effect of liver transplantation in patients with polycystic liver disease
10.3760/cma.j.cn113884-20241205-00364
- VernacularTitle:肝移植治疗多囊肝病患者的疗效分析
- Author:
Anhua DONG
1
;
Yanfen DAI
;
Yandong SUN
;
Hui ZHANG
;
Jinzhen CAI
;
Yuan LIU
Author Information
1. 青岛大学附属医院器官移植中心，青岛 266003
- Publication Type:Journal Article
- Keywords:
Liver disease;
Liver transplantation;
Polycystic liver;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(4):253-257
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the treatment outcome of liver transplantation for patients with polycystic liver disease (PLD).Methods:Clinical data of 28 PLD patients admitted to the Affiliated Hospital of Qingdao University from May 2014 to November 2023 were retrospectively analyzed, including 10 males and 18 females, aged (50.4±6.6) years. Patients were divided into liver transplantation group ( n=15) and non-liver transplantation group ( n=13). In the liver transplantation group, we analyzed seve-ral critical parameters including methods of liver transplantation, intra-abdominal fluid volume, intraoperative blood loss, intraoperative red blood cell transfusion requirements, and postoperative complications. The prognosis of the two groups were also compared. Results:Among the 28 patients with PLD, 15 underwent liver transplantation, including 11 classic in situ liver transplantations, one modified back-to-back liver transplantation, and three liver-kidney combined transplantations. The 15 patients had 2 000 (300, 4 000) ml of abdominal fluid, 1 000 (600, 2 000) ml of intraoperative blood loss, and 8.0 (6.0, 17.0) U of red blood cells transfused during the operation. Postoperative complications occurred in eight cases, with four of which were managemed successfully, and the other four died. The 1-, 5-, and 10-year survival rates of after liver transplantation were 80.0%, 80.0%, and 73.3%, respectively. The 1-, 5-, and 10-year survival rates of patients with PLD without liver transplantation were 69.2%, 46.2%, and 38.5%, respectively. The difference between the two groups was statistically significant ( χ2=3.91, P=0.048). Conclusion:Liver transplantation is a treatment option for patients with PLD, with a better long-term survival compared to patients without liver transplantation.
