Effects of sevoflurane+propofol general anesthesia on immune function and cognitive function in patients with laparoscopic inguinal hernia repair
10.3969/j.issn.1000-484X.2025.02.025
- VernacularTitle:七氟烷+丙泊酚全麻对腹腔镜腹股沟疝修补术患者免疫功能与认知功能的影响
- Author:
Yan XU
1
;
Hao HUA
1
Author Information
1. 苏州大学附属无锡市第九人民医院麻醉科,无锡 214000
- Publication Type:Journal Article
- Keywords:
Sevoflurane;
Propofol;
General anesthesia;
Laparoscopic inguinal hernia repair;
Immune function;
Cognitive func-tion
- From:
Chinese Journal of Immunology
2025;41(2):408-412
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of sevoflurane combined with propofol general anesthesia on immune function and cognitive function in patients undergoing laparoscopic inguinal hernia repair.Methods:A total of 120 patients with laparoscopic inguinal hernia repair treated in Wuxi Ninth People's Hospital Affiliated to Soochow University from January 2021 to March 2022 were randomly divided into control group and observation group.They were operated under general anesthesia.Control group were given pro-pofol intravenous pump,and observation group were given sevoflurane combined inhalation+propofol intravenous pump.The vital signs(mean arterial pressure,heart rate),postoperative pain(VAS score),immune function[T cell subsets(CD3+T,CD4+T,CD8+T,CD4+T/CD8+T),IgG,IgA,IgM],cognitive function(MMSE score,incidence of cognitive impairment)and adverse reac-tions(nausea and vomiting,dizziness,drowsiness,respiratory depression and body movement)were observed.Results:The mean ar-terial pressure at 10 min after laryngeal mask implantation,at the beginning of operation and 10 min after laryngeal mask removal in the two groups were lower than that before anesthesia induction(P<0.05),the heart rate at the beginning of operation in the control group was lower than that before anesthesia induction(P<0.05),and the mean arterial pressure and heart rate in each time period in the two groups were similar(P>0.05);the VAS scores of the observation group were lower than those of the control group(P<0.05);The levels of CD3+T,CD4+T,CD4+T/CD8+T,IgG,IgA,IgM in the observation group were higher than those in the control group(P<0.05),and CD8+T was lower than those in the control group 1 day after operation(P<0.05);the MMSE score and the incidence of cog-nitive impairment were similar in the two groups 1 day after operation(P>0.05);the incidence of adverse reactions in the two groups were similar(P>0.05).Conclusion:Sevoflurane combined with propofol general anesthesia has a good effect in laparoscopic inguinal hernia repair.It can stabilize patients'intraoperative vital signs,reduce postoperative pain,improve immune function indexes,and does not increase the incidence of postoperative cognitive impairment and adverse reactions.
