New perspectives on ferroptosis and its role in liver cancer
10.3760/cma.j.cn113884-20241023-00314
- VernacularTitle:细胞铁死亡在肝癌调控中的研究进展
- Author:
Xinyi JIANG
1
;
Yanran WANG
;
Pinru DI
;
Shiyi QIAN
;
Yahui LIU
;
Haitao JIANG
Author Information
1. 杭州医学院临床医学院临床医学系，杭州 310000
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Liver cancer;
Regulation
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(5):388-391
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is the second most common cause of cancer-related mortality, and exploring effective cure methods for liver cancer has become a major challenge. Ferroptosis is an iron-dependent pattern of cell death caused by the accumulation of lipid peroxides. The main mechanisms of ferroptosis include iron metabolism disorders, imbalance of the antioxidant system, and accumulation of lipid peroxides. Inducing ferroptosis of hepatoma cells is regarded as a potential therapeutic strategy for liver cancer. This article aims to outline the key regulatory signaling pathways of ferroptosis in the occurrence and development of liver cancer, and to deeply analyze the potential application prospects of the ferroptosis mechanism in the field of liver cancer treatment.
